Guillain-Barré syndrome (GBS)

Last Updated on January 23, 2022 by frcemuser

It is an autoimmune response to infections (often Campylobacter infection – around 50% of viral)
characterised by ascending paralysis, starting with tingling and numbness of the fingers and toes, with decreased or absent reflexes
Diagnosis is largely clinical, however, lumbar puncture can be useful. There can be elevated CSF protein levels with a normal WCC. EEG studies can also aid diagnosis.
The treatment of GBS is with supportive measures.
Serial spirometry is used to assess need for intubation and ventilatory support.
All patients with a FVC <20mL/kg require ITU support and will likely need intubation.
Treatment options for GBS are plasma exchange or IV immunoglobulins

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