Guillain-Barré syndrome (GBS)

Last Updated on by frcemuser

  • It is an autoimmune response to infections (often Campylobacter infection – around 50% of viral)
  • characterised by ascending paralysis, starting with tingling and numbness of the fingers and toes, with decreased or absent reflexes
  • Diagnosis is largely clinical, however, lumbar puncture can be useful. There can be elevated CSF protein levels with a normal WCC. EEG studies can also aid diagnosis.
  • The treatment of GBS is with supportive measures.
  • Serial spirometry is used to assess need for intubation and ventilatory support.
  • All patients with a FVC <20mL/kg require ITU support and will likely need intubation.
  • Treatment options for GBS are plasma exchange or IV immunoglobulins

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